Development of new asymmetric reductions

Keywords

asymmetric hydrogenation, asymmetric transfer hydrogenation, enantioselectivity, dynamic kinetic resolution, pharmaceutical compounds, Ru- and Rh-catalysis

Research Themes

• Organometallic complexes
• Asymmetric transfer hydrogenation
• Asymmetric hydrogenation
• Chiral building blocks

Members

• Virginie Vidal| 📧
• Phannarath Phansavath| 📧

Selected recent publications:

1. L. Bacheley, G. Guillamot, P. Phansavath, V. Ratovelomanana-Vidal, Asymmetric transfer hydrogenation of fluorinated ketone and imine derivatives: an efficient access to valuable building blocks, Tetrahedron 2024, 152, 133781 (Special issue “Asymmetric hydrogenation and transfer hydrogenation”).
2. L. Bacheley, R. Ravindra, G. Guillamot, P. Phansavath, V. Ratovelomanana-Vidal, Access to Enantioenriched β-Hydroxy gem-Difluorinated Heterocyclic and Acyclic Derivatives through Rh(III)-Catalyzed Asymmetric Transfer Hydrogenation, Adv. Synth. Catal. 2024, 366, 1019–1023.
3. L. Bacheley, J. Boutet, G. Guillamot, P. Gilles, J. Martin, P. Phansavath, V. Ratovelomanana-Vidal, Stereoselective Access to β-gem-Difluorinated Alcohols Through Enzymatic Reduction, Adv. Synth. Catal. 2024, 366, 3511–3515 (Special issue: Fluorine in Chemistry).
4. L. Bacheley, R. Molina Betancourt, R. Ravindra, G. Guillamot, P. Phansavath, V. Ratovelomanana-Vidal, Asymmetric Synthesis of Monofluorinated Carbocyclic Alcohols and Vicinal Difluorinated Heterocycles and Carbocycles, Eur. J. Org. Chem. 2023, 26, e202300383. (selected as Very Important Paper, Special thematic issue “Asymmetric Synthesis and Catalysis”)
5. R. Molina Betancourt, L. Bacheley, A. Karapetyan, G. Guillamot, P. Phansavath, V. Ratovelomanana-Vidal, An Environmentally Sustainable Synthesis of Enantioenriched CF₃-Chromanol, Indanol and Tetralol Derivatives by Rh-Catalyzed Asymmetric Transfer Hydrogenation, ChemCatChem 2022, 14, e202200595. (Highlighted in Advances in Chemical Engineering)
6. J.-P. Genêt, P. Phansavath, V. Ratovelomanana-Vidal, Asymmetric Hydrogenation: Design of Chiral Ligands and Transition Metal Complexes. Synthetic and Industrial Applications, Isr. J. Chem. 2021, 61, 409–426.
7. R. Molina-Betancourt, P. Phansavath, V. Ratovelomanana-Vidal, Rhodium-Catalyzed Asymmetric Transfer Hydrogenation/Dynamic Kinetic Resolution of 3‐Benzylidene-Chromanones, Org. Lett. 2021, 23, 1621–1625. (Selected for Organic Chemistry Portal)
8. F. Wang, L.-S. Zheng, Q.-W. Lang, C. Yin, T. Wu, P. Phansavath, G.-Q. Chen, V. Ratovelomanana-Vidal, X. Zhang, Rh(III)-catalyzed diastereoselective transfer hydrogenation：an efficient entry to key intermediates of HIV protease inhibitor, Chem. Comm. 2020, 56, 3119–3122

Main Collaborations and partners

• PCAS
• Seqens
• Orgapharm